Institute of Toxicology
Ministry of Health, Russia

Director	A. N. Petrov	MD, PhD, Professor
Deputy-Director	S.P. Nechiporenko	MD, PhD, Professor
Chief of chemical laboratory	I. N. Somin	PhD
Leading Researcher	I. K. Zhurkovich	PhD
Senior Researcher	M.A. Zaitseva	PhD

Staff: 267
Leading Researchers: 28
Senior Researchers: 26
Researcher: 29
Assistant Researcher: 19
Anatomists: 6
Laboratory assistants: 42
Engineers: 42
Other staff: 75

Types of research

• drug development, screening and discovery and toxicology testing:
  general and specific toxicity study;
• specific pharmacology drug study:
  • neuroleptic activity,
  • antidepressant activity,
  • hypnotic activity,
  • anticonvulsant activity,
  • antiparkinsonian activity,
  • analgetic activity,
  • antialcoholic activity,
  • antiarhythmic activity,
  • hepatoprotective action,
  • anti-inflammation activity,
  • immunological activity;
• pharmacokinetic and toxicokinetic studies
  • gas liquid chromatography ,
  • high performance liquid chromatography,
  • atomic absorbance spectrometry,
  • spectrophotometry,
  • fluorometry.

Research is carried out on different laboratory animals (the mice, rats, rabbits, guinea pigs, dogs) using various means of administration: per os, all parenteral, contact, inhalation and other.

The institute is divided into nine laboratory divisions.

General areas of interest: drug development, screening and discovery and toxicology testing, analytical researches.

Experience with the western companies: 1998-2000 Novelos (USA)
Experimental preclinical Study of general toxic, specific toxic effects, specific pharmacological effects and pharmacokinetics of Glutoxim.

Future plans: vivarium renovation, modernization of laboratory capacities, and GLP certification through the BioIndustry Initiative.

Needs: Modern equipment for carrying out preclinical physiological, biochemical, pathomorphic and analytical researches.

Intellectual property

• RU №2133245 «New thetramine with selective affinity to 2-cholinereceptors»
• RU №2155759 «Acetylene amino spirits with M-cholinelitic properties»
• RU №2155533 « The method of diagnostics of disturbance of use of oxygen tissues at poisonings»
• RU № 2184542 «Hydrochloride 1phenyl-1-cyclopentyl-4-piperydinol-2-butyn-1-ol (Pentifine), Antiparkinsonian activity »
• RU №2169559 «Perftoran application for gas-poisoning lung treatment» and other. (all 12 patents).