Institute of Toxicology, St. Petersburg
Director: A. N. Petrov, MD, PhD, Professor
Deputy-Director: S.P. Nechiporenko, MD, PhD, Professor
Chief of chemical laboratory: I. N. Somin, PhD
Leading Researcher: I. K. Zhurkovich, PhD
Senior Researcher: M.A. Zaitseva, PhD
First Annual Chemical Science and Commercialization Conference
Presentations
-
Introduction:
(English)
(Russian)
- "Drug preclinical testing in Institute of Toxicology" (English) (Russian)
- Drug preclinical testing in Institute of toxicology of Health Ministry of Russia on an example of Acizol preclinical study
- Analytical Chemistry in Drug Development
- Pharmacological and toxicological studies of new drug substances at Institute of Toxicology of the Russian Federation Ministry of Health
- Synthesis And Technology Of Drug Substances At Institute Of Toxicology
Staff: 267
Leading Researchers: 28
Senior Researchers: 26
Researcher: 29
Assistant Researcher: 19
Anatomists: 6
Laboratory assistants: 42
Engineers: 42
Other staff: 75
Types of research
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drug development, screening and discovery and toxicology testing:
general and specific toxicity study; -
specific pharmacology drug study:
- neuroleptic activity,
- antidepressant activity,
- hypnotic activity,
- anticonvulsant activity,
- antiparkinsonian activity,
- analgetic activity,
- antialcoholic activity,
- antiarhythmic activity,
- hepatoprotective action,
- anti-inflammation activity,
- immunological activity;
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pharmacokinetic and toxicokinetic studies
- gas liquid chromatography ,
- high performance liquid chromatography,
- atomic absorbance spectrometry,
- spectrophotometry,
- fluorometry.
Research is carried out on different laboratory animals (the mice, rats, rabbits, guinea pigs, dogs) using various means of administration: per os, all parenteral, contact, inhalation and other.
The institute is divided into nine laboratory divisions.
General areas of interest: drug development, screening and discovery and toxicology testing, analytical researches.
Experience with the western companies: 1998-2000 Novelos (USA)
Experimental preclinical Study of general toxic, specific toxic effects, specific pharmacological effects and pharmacokinetics of Glutoxim.
Future plans: vivarium renovation, modernization of laboratory capacities, and GLP certification through the BioIndustry Initiative .
Needs: Modern equipment for carrying out preclinical physiological, biochemical, pathomorphic and analytical researches.
Intellectual property
- RU No2133245 «New thetramine with selective affinity to 2-cholinereceptors»
- RU No2155759 «Acetylene amino spirits with M-cholinelitic properties»
- RU No2155533 « The method of diagnostics of disturbance of use of oxygen tissues at poisonings»
- RU No 2184542 «Hydrochloride 1phenyl-1-cyclopentyl-4-piperydinol-2-butyn-1-ol (Pentifine), Antiparkinsonian activity »
- RU No2169559 «Perftoran application for gas-poisoning lung treatment» and other. (all 12 patents).